William Neal Reynolds Professor of Statistics and Genetics
Bioinformatics Research Center
Departments of Statistics and Genetics
North Carolina State University
1521 Partners II
Building, 840 Main Campus Drive
Raleigh, NC 27695-7566
Tel: (919) 515-1942; FAX: (919) 515-7315
Email: zeng@stat.ncsu.edu
Education
1982 B.Sc. Animal Science, Huazhong Agricultural
University, Wuhan, China
1986
Ph.D. Genetics, University of
Edinburgh, Edinburgh, Scotland, UK, Advisor: Prof.
W. G. Hill
Positions
1982—1983 Department
of Animal Science, Huazhong Agricultural University,
Wuhan, China,
Assistant Lecturer
1983—1986 Department
of Genetics, University of Edinburgh, Edinburgh, Scotland, UK,
Graduate Student
1986—2001 Department
of Statistics, North Carolina State University
Postdoctoral Research Associate (1986-1990) (with Prof. C. Clark Cockerham)
Visiting Assistant Professor (1990-1991)
Research Assistant Professor (1992-1994)
Research Associate Professor (1994-1999)
Research Professor (1999-2001)
2001— Departments
of Statistics, Genetics & Bioinformatics Research Center, N C State
University
Professor (2001-2005)
William Neal Reynolds Professor (2005-)
2006— Director,
Bioinformatics Research Center, N C State University
2006— Director,
Bioinformatics Graduate Program, N C State University
Adjunct/Visiting Appointments
1995
Visiting Professor, China
Agricultural University, Beijing, China
1995
Adjunct Professor, Huazhong Agricultural
University, Wuhan, China
1999
Adjunct Professor, Nanjing Forestry University, Nanjing, China
2000
Adjunct Professor, Zhejiang University, Hangzhou, China
2004
Visiting Professor, Edinburgh University, Edinburgh,
Scotland, UK (sabbatical)
Honors and Awards
1998 China
Bridge International Fellow
2001
D. D. Mason Faculty
Award, Department of Statistics, North Carolina State University
2005
William
Neal Reynolds Professorship
2008 Fellow of the American
Statistics Association
Professional Activities
·
1994—2002 Associate Editor, GENETICS
·
1995—2000 Associate Editor, THEORETICAL POPULATION
BIOLOGY
·
2001—
Editorial Board, JOURNAL OF ZHEJIANG
UNIVERSITY (Agri. & Life Sci.)
·
2004—
Editorial Board, ACTA
GENETICA SINICA
·
2005—2008 Associate Editor, BMC GENETICS
·
2006—2010 Editorial Board, ACTA AGRONOMICA
SINICA
·
1996-1997 NSF
Computational Biology Activities Review Panel
·
1996, 1997 NIH/NHLBI Special
Emphasis Review Pane
·
1997
USDA/ARS Animal Genome and Genetical
Mechanisms Review Panel
·
2000
NIH/NHGRI Genome Research Review Committee
·
2002
NIH Genome Study Section (Ad hoc in June)
·
2002-2006 NIH/NIGMS
Biomedical Research and Research Training Committee
·
2005
NIH Genomics, Computational Biology and Technology Study
Section
·
2005
Joint NSF-NIGMS Mathematical Biology Panel
·
2006
NIEHS Director's Challenge Initiatives Program Review
·
1995
Organizer of invited symposium on “Mapping Quantitative
Trait Loci”, Annual Meeting of the Society for the Study of Evolution,
Montreal, Canada
·
1998
Organizer of invited symposium on “Mapping and
Characterizing Genes Affecting Quantitative Traits”, The XVIIIth
International Congress of Genetics, Beijing, China
·
2001
Vice Chairman of “International Symposium on Mapping
and Identification of Genes for Complex Polygenic Traits and Diseases”,
Changsha, Human, China
·
2002-2005 Representative
of the Eastern and Western North American Regions of the International Biometric Society
(ENAR/WNAR)
to Section G: Biological Sciences of the American
Association for the Advancement of Science (AAAS)
·
2004
Organizer of invited session on “Gene Expression QTL
Analysis”, The Joint Statistics Meetings, Toronto
·
2006-7
Co-Chair of the Organizing Committee for the Third International Conference on
Quantitative Genetics, August 18-24, 2007, Hangzhou, China
·
1993-1995 Consultant to
Pioneer Hi-Bred International Inc.
·
1994-1996 Consultant to Ciba
Geigy
·
2000-2002 Consultant to
Monsanto/Cereon Genomics
·
2005
Consultant to BASF Plant Science
Publications
1.
Zeng, Z.-B. (1986) Theoretical studies on
genetic limits to natural and artificial selection with mutation. Ph.D Thesis, Department of Genetics, The
University of Edinburgh.
2.
Zeng, Z.-B. and W.G.
Hill (1986) The
selection limit due to the conflict between truncation and stabilizing
selection with mutation. Genetics 114:1313-1328. [Abstract]
3.
Zeng, Z.-B. (1987) Genotypic
distribution at the limit to natural and artificial selection with mutation. Theoretical
Population Biology 32:90-113. [Abstract]
4.
Zeng, Z.-B. (1988) Long-term correlated
response, interpopulation covariation
and interspecific allometry.
Evolution 42: 363-374. [Abstract]
5.
Zeng, Z.-B., H. Tachida
and C.C. Cockerham (1989) Effects of mutation on
selection limits in finite populations with multiple alleles. Genetics
122:977-984.
[Abstract]
6.
Zeng, Z.-B. (1989) A genetic model of interpopulation variation and covariation
of quantitative characters. Genetical
Research 53:215-221. [Abstract]
7.
Zeng, Z.-B., D. Houle
and C.C. Cockerham (1990) How
informative is Wright's estimator of the number of genes affecting a
quantitative character? Genetics 126:235-247. [Abstract]
8.
Zeng, Z.-B. and C.C. Cockerham (1990) Long-term response to artificial selection
with multiple alleles---Study by simulations. Theoretical Population Biology
37: 254-272. [Abstract]
9.
Zeng, Z.-B. and H. Tachida (1990) How important is mutation for selection
responses? In Proceedings of the 4th World Congress on Genetics Applied to
Livestock Production 13: 301-305.
10.
Zeng, Z.-B. and C.C. Cockerham (1991) Variance of neutral
genetic variances within and between populations for a quantitative character.
Genetics 129:535-553. [Abstract]
11.
Zeng, Z.-B. (1992) Correcting the bias of
Wright's estimates of the number of genes affecting a quantitative
character---A further improved method. Genetics 131:
987-1001. [Abstract]
12.
Zeng, Z.-B. and C.C. Cockerham (1993) Mutation models and
quantitative genetic variation. Genetics 133: 729-736. [Abstract]
13.
Zeng, Z.-B. (1993) Theoretical basis of
separation of multiple linked gene effects on mapping quantitative trait loci.
Proceedings of the National Academy of Science USA 90:10972-10976.
[Abstract]
14.
Zeng, Z.-B. (1994) Precision mapping of
quantitative trait loci. Genetics 136: 1457-1468. [Abstract]
15.
Zeng, Z.-B. (1994) A composite interval mapping
method for locating multiple QTLs. Proceedings of the 5th World Congress on
Genetics Applied to Livestock Production 21: 37-40.
16.
Basten, C.J., B.S.
Weir and Z.-B. Zeng (1994) ZMAP---A QTL Cartographer. Proceedings of
the 5th World Congress on Genetics Applied to Livestock Production 22:65-66.
17.
Jiang, C. and Z.-B. Zeng (1995) Multiple trait analysis
of genetic mapping for quantitative trait loci. Genetics 140:
1111-1127. [Abstract]
18.
Dragani, T. A., Z.-B.
Zeng, F. Canzian, M. Gariboldi,
G. Manenti and M. A. Pierotti
(1995) Molecular mapping of body weight loci on mouse chromosome X. Mammalian
Genome 6: 778-781. [Abstract]
19.
Liu, J. J. M. Mercer, L. F. Stam,
G. C. Gibson, Z.-B. Zeng and C.C. Laurie (1996) Genetic analysis of a
morphological shape difference in the male genitalia of Drosophila simulans and D. mauritiana.
Genetics 142:1129-1145. [Abstract]
20.
Cockerham, C. C. and Z.-B.
Zeng (1996) Design
III with marker loci. Genetics 143:1437-1456. [Abstract]
21.
Zeng, Z.-B. and B. S.
Weir (1996) Statistical methods for mapping quantitative trait loci. Acta Agronomica Sinica 22: 535-549.
22.
Zeng, Z.-B. (1997) Combining information from
data in mapping analysis: use of multiple markers and multiple traits. Animal
Biothechnology 8:145-150.
23.
Kao, C.-H. and Z.-B. Zeng
(1997) General
formulae for obtaining the MLEs and the asymptotic variance-covariance matrix
in mapping quantitative trait loci when using the EM algorithm. Biometrics 53: 653-665. [Abstract]
24.
True, J. R., J. Liu, L. F. Stam, Z.-B. Zeng and C. C. Laurie, (1997) Quantitative genetic analysis of divergence in male
secondary sexual traits between Drosophila simulans
and Drosophila mauritiana. Evolution 51:816-832.
[Abstract]
25.
Nuzhdin, S. V., E.
G. Pasyukova, C. L. Dilda, Z.-B.
Zeng and T. F. C. Mackay (1997) Sex-specific quantitative
trait loci affecting longevity in Drosophila melanogaster.
Proceedings of the National Academy of Science USA 94: 9734-9739.
[Abstract] [Full Text] [PDF] [Data]
26.
Doerge, R. W., Z.-B.
Zeng and B. S. Weir (1997) Statistical
issues in the search for genes affecting quantitative traits in experimental
populations. Statistical Science 12: 195-219. [Abstract]
27.
Jiang, C. and Z.-B. Zeng (1997) Mapping quantitative trait
loci with dominant and missing markers in various crosses from two inbred lines.
Genetica 101:47-58. [Abstract]
28.
Kao, C.-H., Z.-B. Zeng and R. D. Teasdale (1999) Multiple interval
mapping for quantitative trait loci. Genetics 152:1203-1216. [Abstract] [Full Text]
29.
Weber, K., R. Eisman, S. Higgins,
L. Kuhl, A. Patty, J. Sparks and Z.-B. Zeng
(1999) An analysis of polygenes affecting
wing shape on chromosome three in Drosophila melanogaster.
Genetics 153: 773-786. [Abstract] [Full Text] [Data]
30.
Zeng, Z.-B., C.-H. Kao, and C. J. Basten (1999) Estimating
the genetic architecture of quantitative traits. Genetical
Research 74:279-289. [Abstract]
31.
Vieira, C., E. G. Pasyukova, Z.-B.
Zeng, J. B. Hackett, R. F. Lymanand, T. F. C.
Mackay (2000) Genotype-environment
interaction for quantitative trait loci affecting lifespan in Drosophila melanogaster. Genetics 154:213-227. [Abstract] [Full Text] [Data]
32.
Zeng, Z.-B., J. Liu, L. F. Stam,
C.-H. Kao, J. M. Mercer and C.C. Laurie (2000) Genetic architecture
of a morphological shape difference between two Drosophila species. Genetics
154: 299-310. [Abstract] [Full Text] [ Data]
33.
Wu, R., B. Li and Z.-B. Zeng (2000) Molecular dissection
of quantitative traits: new perspectives from Populus.
pp. 475-490 in ``Molecular Biology of Woody Plants'' edited by S. M. Jian and S. C. Minocha, Kluwer Academic Publishers, The Netherlands.
34.
Wu, R.L., Z.-B. Zeng, D. M. O'Malley, S. E. McKeand and R. R. Sederoff (2000) The
case for molecular mapping in forest tree breeding. Plant Breeding Reviews
19: 41-68.
35.
Liu, Y. and Z.-B. Zeng (2000) A general mixture model approach for mapping quantitative
trait loci from diverse cross experimental designs involving multiple inbred
lines . Genetical Research 75: 345-355.
[ Abstract]
36.
Wu, R.L., Y.F. Han, J.J. Hu, J.J.
Fang, L. Li, M.L. Li. and Z.-B. Zeng (2000) An integrated genetic map of Populus
deltoides based on amplified fragment length
polymorphisms. Theoretical and Applied Genetics 100:
1249-1256. [ Abstract]
37.
Luo, Z.L., S.
H. Tao and Z.-B. Zeng (2000) Inferring
linkage disequilibrium between a polymorphic marker locus and a trait locus in
natural populations. Genetics 156: 457-467. [Abstract]
38.
Wu, R.L., and Z.-B. Zeng (2001) Joint linkage and linkage disequilibrium mapping in
natural populations. Genetics 157:899-909. [Abstract] [Full Text]
39.
Yin, T.M., M.R. Huang, M.X. Wang, L.H. Zhu, Z.-B. Zeng and
R.L. Wu (2001) Preliminary interspecific genetic maps
of the Populus genome constructed from RAPD markers. Genome
44 (4): 602-609.
40.
Wu, R.L., M. Gallo-Meagher, R. C. Littell,
and Z.-B. Zeng (2001) A General Polyploid Model for Analyzing Gene Segregation in Outcrossing Tetraploid Species.
Genetics 159: 869-882. [Abstract] [Full Text]
41.
Weber, K., R. Eisman, S. Higgins,
L. Morey, A. Patty, M. Tausek and Z.-B. Zeng
(2001) An analysis of polygenes affecting
wing shape on chromosome 2 in Drosophila melanogaster.
Genetics 159: 1045-1057. [Abstract] [Full Text]
[Data]
42.
Wu, S. S., R. Wu, C.-X. Ma, Z.-B. Zeng, M. C. K. Yang
and G. Casella (2001) A
multivalent pairing model of linkage analysis in autotetraploids.
Genetics 159: 1339-1350. [Abstract] [Full Text]
43.
Z.-B. Zeng (2001) Quantitative trait loci:
statistical methods for mapping their positions. Encyclopedia of Genetics
(edited by Eric. C. R. Reeve) Fitzroy Dearborn Publishers, London.
44.
Kao, C.-H. and Z.-B. Zeng
(2002) Modeling epistasis of quantitative trait loci using Cockerham's model. Genetics 160:
1243-1261. [Abstract]
[Full Text]
45.
Wu, R., C.-X. Ma, S. S. Wu and Z.-B. Zeng (2002) Linkage mapping
of sex-specific differences. Genetical
Research 79: 85-96. [Abstract]
46.
Wu, R.L., C.-X. Ma, I. Painter and Z.-B. Zeng (2002) Simultaneous maximum likelihood estimation of linkage and
linkage-phases in outcrossing species. Theoretical
Population Biology 61: 349-363. [Abstract]
47.
Z.-B. Zeng (2002) QTL Mapping. Encyclopedia
of Genetics (edited by S. Brenner and J. H. Miller) Vol
3:1587-1593, Academic Press, San Diego.
48.
Balding DJ, Carothers AD, Marchini
JL, Cardon LR, Vetta A,
Griffiths B, Weir BS, Hill WG, Goldstein D, Strimmer
K, Myers S, Beaumont MA, Glasbey CA, Mayer CD,
Richardson S, Marshall C, Durrett R, Nielsen R, Visscher PM, Knott SA, Haley CS, Ball RD, Hackett CA,
Holmes S, Husmeier D, Jansen RC, ter
Braak CJF, Maliepaard CA,
Boer MP, Joyce P, Li N, Stephens M, Marcoulides GA, Drezner Z, Mardia K, McVean G, Meng XL, Ochs MF, Pagel M, Sha N, Vannucci M, Sillanpaa MJ, Sisson S, Yandell
BS, Jin CF, Satagopan JM, Gaffney PJ, Zeng ZB,
Broman KW, Speed TP, Fearnhead P, Donnelly P, Larget B, Simon DL, Kadane JB,
Nicholson G, Smith AV, Jonsson F, Gustafsson
O, Stefansson K, Donnelly P, Parmigiani G, Garrett
ES, Anbazhagan R, Gabrielson
E (2002) Discussion
on the meeting on 'Statistical modelling and analysis
of genetic data', Journal of the Royal Statistical Society,
Series B-Statistical Methodology 64: 737-775 Part 4.
49.
Tao, Y., Z.-B. Zeng, J. Li, D. L. Hartl
and C. C. Laurie (2003) Genetic dissection of
hybrid incompatibilities between Drosophila simulans
and Drosophila mauritiana, II. Mapping hybrid
male sterility loci on the third chromosome. Genetics 164:1399-1418
[Abstract]
[Full Text]
50.
Z.-B. Zeng (2003) Quantitative Trait Loci
Mapping. Encyclopedia of the Human Genome (edited by David Cooper).
Macmillan Publishers Ltd, Nature Publishing Group.
51.
Zeng, Z.-B. (2005) QTL mapping and the
genetic basis of adaptation: recent developments. Genetica
123: 25-37. [Also published in Georgia Genetics Review III:
Genetics of Adaptation. Edited by Rodney Mauricio (2005) pp.25-37.
Springer]
52.
Zeng, Z.-B., T. Wang and W. Zou
(2005) Modeling
quantitative trait loci and interpretation of models. Genetics 169:1711-1725.
53.
Kirst, M., C. J. Basten, A. A. Myburg, Z.-B.
Zeng and R. R. Sederoff (2005) Genetic architecture
of transcript level variation in differentiating xylem of an
Eucalyptus hybrid. Genetics 169:2295-2303.
54.
Liu, L. and Z.-B. Zeng (2005) Mixture model equations for
marker-assisted genetic evaluation. J. Anim. Breed. Genet.
122: 229-239.
55.
Wang, T., and Z.-B. Zeng (2006) Modeling
quantitative trait loci with epistasis and linkage
disequilibrium in experimental and natural populations. BMC Genetics
7:9.
56.
Wang, T., B.S. Weir and Z-.B. Zeng (2006) A
population-based latent variable approach for association mapping of
quantitative trait loci. Annals of Human Genetics 70: 506-523.
57.
Li, J., S. Wang and Z.-B. Zeng (2006) Multiple interval
mapping for ordinal traits. Genetics 173: 1649-1663.
58.
Zou, W., D.L. Aylor and Z.-B. Zeng (2007) eQTL
Viewer: Visualizing how sequence variation affects genome-wide transcription.
BMC Bioinformatics 8:7.
59.
Melchinger, A.E., H.F. Utz, H.P. Piepho, Z.-B. Zeng, and C.C. Schon (2007) Quantitative genetic theory to elucidate the
role of epistasis in the manifestation of heterosis. Genetics
177: 1815-1825.
60.
Lai, C.-Q., J. Leips, W. Zou, J. M. Roberts, K.
R. Wollenberg, L. D. Parnell, Z.-B. Zeng, J. M. Ordovas and T. F. C.
Mackay (2007) Speed-mapping quantitative trait loci using microarrays. Nature Methods 4(10):839-841.
61.
Yang, R., H. Gao, X. Wang, J. Zhang, Z.-B. Zeng and R. Wu (2007) A semiparametric approach for composite functional mapping of
dynamic quantitative traits. Genetics
177: 1859-1870.
62.
Kim, Y., S. Feng and Z.-B. Zeng
(2008) Measuring and partitioning the high order linkage disequilibrium by
multiple order Markov chains. Genetic Epidemiology 32:301-312.
63.
Zou, W. and Z.-B. Zeng (2008) Multiple interval
mapping for gene expression QTL analysis. Genetica (submitted)
64.
Aylor, D.L. and Z.-B.
Zeng (2008) From classic genetics to quantitative
genetics to systems biology: the role of epistasis. PLoS Genetics 4(3).
65.
Garcia, A. A. F.,
S. Wang, A. E. Melchinger and Z.-B. Zeng (2008) QTL mapping and the genetic basis of heterosis in maize and rice. Genetics (submitted).
66.
Huang, L., A. S. Heinloth, Z.-B. Zeng.
R. S. Paules and P.R. Bushel (2008) Genes related to apoptosis predict necrosis
of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants. BMC
Genomics (submitted).
67.
Zou, W. and Z-.B
Zeng (2008) Statistical methods for QTL mapping. International Journal of Plant Genomics (submitted).
Software
1.
Basten, C., B. S.
Weir and Z.-B. Zeng (1995-2005) QTL Cartographer. Department of
Statistics, North Carolina State University, Raleigh, NC
2.
Wang, S., C. Basten and Z.-B.
Zeng (2001-2005) WINDOWS
QTL Cartographer. Department of Statistics, North Carolina State
University, Raleigh, NC
3.
Zou, W., D.L. Aylor and Z.-B. Zeng (2006) eQTL
Viewer. Bioinformatics Research Center, North Carolina State University,
Raleigh, NC
Teaching
ST
372 “Introduction of
Statistical Inference and Regression” (Summer 1992)
ST/GN
790 “Statistical Methods of Mapping Quantitative Trait Loci”
(Fall 1994,1996, 1998)
ST/GN
770 “Statistical Concepts in Genetics” (Spring 2000, 2003,
2005) (jointly with Bruce Weir)
ST/GN
757 “Statistics for Molecular Quantitative Genetics” (Fall
2000, 2002, 2004, 2006, 2008)
ST 610E “QTL Mapping” (Fall
2000-2005) (Web-based Distance Learning course)
Short Courses
·
1996-2005 Summer
Institute of Statistical Genetics “Mapping Quantitative Trait Loci I and II”,
NC State University, Raleigh NC
· 2006- Summer Institute of Statistical Genetics “Mapping Quantitative Trait Loci I an